| Bioactivity | QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1]. | |||||||||
| Name | QO 58 | |||||||||
| CAS | 1259536-62-3 | |||||||||
| Formula | C18H8Cl2F4N4O | |||||||||
| Molar Mass | 443.18 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Zhang F, et al. Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol. 2013;168(4):1030-1042. |
QO 58
CAS: 1259536-62-3 F: C18H8Cl2F4N4O W: 443.18
QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent acti
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