| Bioactivity | QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1.25 μM)[1][2]. |
| Target | vEC50: 1.25 μM (oltage-gated M-type potassium channel) |
| Invitro | QO-40 (100 μM) 可上调 CHO 细胞中的 KCNQ2/3 电流[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> QO-40 相关抗体: Cell Viability Assay[1] Cell Line: |
| CAS | 1259536-70-3 |
| Formula | C18H11ClF3N3O |
| Molar Mass | 377.75 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology. 2011;87(5-6):297-310. |