| Bioactivity | QAQ dichloride dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain[1][2]. |
| Target | Target: voltage-gated Nav and Kv channels |
| Invitro | QAQ dichloride dichloride (100 μM) does not cross the membrane and can be injected into cells through a micropipette to photosensitize a single cell and afford subcellular control of action potential propagation. It blocks Shaker-IR current in the?trans?configuration and unblocks it in the?cis?configuration[1].QAQ dichloride dichloride can be used to develop red-shifted derivatives of QAQ dichloride, powerful doubly charged photochromic blockers.These derivatives allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to silence neuronal activity reversibly[2]. |
| Name | QAQ |
| CAS | 1204416-85-2 |
| Formula | C28H44N6O22+ |
| Molar Mass | 496.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Timm Fehrentz, et al. Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. Chembiochem. 2012 Aug 13;13(12):1746-9. [2]. Alexandre Mourot, et al.Photochromic Potassium Channel Blockers: Design and Electrophysiological Characterization. Methods Mol Biol. 2013;995:89-105. |