Pyruvate Carboxylase-IN-5

CAS: F: C13H11FN2O5 W: 294.24

Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyru

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Bioactivity	Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose[1].
Formula	C13H11FN2O5
Molar Mass	294.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Schneider N O, et al. Synthesis and Evaluation of 1, 3-Disubstituted Imidazolidine-2, 4, 5-triones as Inhibitors of Pyruvate Carboxylase[J]. ACS Medicinal Chemistry Letters, 2024.