| Bioactivity | Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM[1]. |
| Target | IC50: 0.608 μM (FAK) |
| Invitro | Pyk2-IN-2 (compound 13j) 对 PYK2 细胞的 IC50 为 55 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Pyk2-IN-2 相关抗体: |
| In Vivo | Pyk2-IN-2 (compound 13j) 的 HLM 血液清除率 为 31 mL/min/kg[1]。在雄性 Wistar-Han 大鼠中的药代动力学分析[1]Route |
| CAS | 1271418-15-5 |
| Formula | C27H27N7O |
| Molar Mass | 465.55 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Bhattacharya SK, et al. Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7523-9. |