| Bioactivity | Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1]. | ||||||||||||
| Invitro | Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC50 of 7.07 μM[1]. | ||||||||||||
| Name | Purvalanol B | ||||||||||||
| CAS | 212844-54-7 | ||||||||||||
| Formula | C20H25ClN6O3 | ||||||||||||
| Molar Mass | 432.90 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gray NS, et, al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. [2]. Bullard KM, et, al. Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites. Malar J. 2015 Apr 8;14:147. |
Purvalanol B
CAS: 212844-54-7 F: C20H25ClN6O3 W: 432.90
Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 n
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