Pt(IV)-M13_product_DataBase

Bioactivity	Pt(IV)-M13 is a BBB-penatrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma[1].
Invitro	Pt(IV)-M13 (1-30 μM；80 小时) 对 G9 神经球的 IC50 约为 5 μM，与顺铂 (HY-17394) 相似[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Pt(IV)-M13 相关抗体:
In Vivo	Pt(IV)-M13 (2.5 mg/kg；尾静脉注射；单剂量) 可在小鼠中显著增加到达大脑的铂含量，比顺铂 (HY-17394) 高 15 倍[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C120H190ClF8N30O28PtS2
Molar Mass	2947.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fadzen CM, et al. A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem. 2020 Jul 9;63(13):6741-6747.

PeptideDB