| Bioactivity | Pseudouridimycin TFA is an antibiotic and a selective bacterial RNA polymerase (RNAP) inhibitor with an IC50 of approximately 0.1 μM and a minimum inhibitory concentration (MIC) of 4 - 6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analog that is active against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and is active in a mouse peritonitis model of infection with Streptococcus pyogenes. |
| CAS | 2760807-99-4 |
| Formula | C19H27F3N8O11 |
| Molar Mass | 600.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maffioli SI, et al. Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):335-343. |
Pseudouridimycin TFA
CAS: 2760807-99-4 F: C19H27F3N8O11 W: 600.46
Pseudouridimycin TFA is an antibiotic and a selective bacterial RNA polymerase (RNAP) inhibitor with an IC50 of approxim
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