Protizinic acid_product_DataBase

Bioactivity	Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM[1][2].
Invitro	Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin[1].
In Vivo	In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1].Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].
Name	Protizinic acid
CAS	13799-03-6
Formula	C17H17NO3S
Molar Mass	315.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. K Suzuki, et al. Effects of protizinic acid on leukokinin generation and its physiological action. Agents Actions. 1984 Jun;14(5-6):699-706. [2]. H Ohnishi, et al. Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9.

PeptideDB