| Bioactivity | Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC50 value of 7 nM. Protease-Activated Receptor-1 antagonist 3 shows binding affinity for hERG K+ channel with an IC50 value of 9 µM[1]. |
| In Vivo | Protease-Activated Receptor-1 antagonist 3 (compound 23) (3 mg/kg; i.v.) shows 10% bioavailability in rats[1]. Animal Model: |
| Name | Protease-Activated Receptor-1 antagonist 3 |
| Formula | C30H34N4O3 |
| Molar Mass | 498.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mandal M, et al. Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery. J Med Chem. 2022 Apr 14;65(7):5575-5592. |
Protease-Activated Receptor-1 antagonist 3
CAS: F: C30H34N4O3 W: 498.62
Protease-Activated Receptor-1 antagonist 3 is a potent protease-activated receptor-1 antagonist with an IC50 value of 7
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