| Bioactivity | Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice[1]. |
| CAS | 3054217-03-4 |
| Formula | C21H14BrN3O2S |
| Molar Mass | 452.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Potenza M, et al. Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors. ACS Med Chem Lett. 2022 Dec 9;14(1):26-34. |
Prostaglandin E2 Inhibitor 3
CAS: 3054217-03-4 F: C21H14BrN3O2S W: 452.32
Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.