| Bioactivity | Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2]. | ||||||
| Invitro | Prosaptide Tx14(A) promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1]. | ||||||
| Name | Prosaptide Tx14(A) | ||||||
| CAS | 196391-82-9 | ||||||
| Sequence | Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr | ||||||
| Shortening | TALIDNNATEEILY | ||||||
| Formula | C69H110N16O26 | ||||||
| Molar Mass | 1579.70 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Prosaptide Tx14(A)
CAS: 196391-82-9 F: C69H110N16O26 W: 1579.70
Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respec
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.