| Bioactivity | Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2]. |
| Invitro | Prosaptide Tx14(A) TFA promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) TFA is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1]. |
| Name | Prosaptide Tx14(A) TFA |
| Sequence | Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr |
| Shortening | TALIDNNATEEILY |
| Formula | C71H111F3N16O28 |
| Molar Mass | 1693.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Prosaptide Tx14(A) TFA
CAS: F: C71H111F3N16O28 W: 1693.72
Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, re
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