| Bioactivity | Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||||||||
| Invitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | |||||||||
| Name | Propargyl-PEG8-NHS ester | |||||||||
| CAS | 2182601-74-5 | |||||||||
| Formula | C24H39NO12 | |||||||||
| Molar Mass | 533.57 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Propargyl-PEG8-NHS ester
CAS: 2182601-74-5 F: C24H39NO12 W: 533.57
Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG
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