Propantheline bromide_product_DataBase

Bioactivity	Propantheline bromide is an orally active mAChR antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination[1][2][3].
Target	mAChR
Invitro	Propantheline bromide (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine[1].
In Vivo	Propantheline bromide (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats[3]. Animal Model:
Name	Propantheline bromide
CAS	50-34-0
Formula	C23H30BrNO3
Molar Mass	448.39
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. J Mokry, et al. Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs. Bratisl Lek Listy. 2005;106(4-5):151-4. [2]. Richard Jewell, et al. Propantheline. xPharm: The Comprehensive Pharmacology Reference. 2007, Pages 1-5. [3]. S Kobayashi, et al. Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo. Jpn J Pharmacol. 2001 Jul;86(3):281-8.

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