Progranulin modulator-3_product_DataBase

Bioactivity	Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research[1].
Invitro	Progranulin modulator-3 (1-30 μM, 48 h) 剂量依赖性地诱导 N2A 细胞产生 PGRN 蛋白[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Progranulin modulator-3 相关抗体:
In Vivo	Progranulin modulator-3 (10 mg/kg, 腹腔注射，24 小时) 在小鼠血浆和脑中的半衰期为 41 分钟，Cmax 分别为 1498 ng/mL 和 6246 ng/g，并增加 Grn+/− 小鼠脑中的 PGRN 蛋白水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	371116-39-1
Formula	C18H12N2O3
Molar Mass	304.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tesla R, et al. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nat Commun. 2024 Jul 20;15(1):6125.

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