| Bioactivity | Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 µM[1]. Procaterol hydrochloride can inhibit inflammation both in vivo and in vitro[2]. |
| Invitro | Procaterol treat inflammation through inhibiting oxidative stress in vitro[2]. Procaterol (25-200 nM) increases the viability of 16HBE cells[2]. Cell Viability Assay[2] Cell Line: |
| In Vivo | Procaterol significantly increases conditioned stimulus (CS)-evoked freezing levels[3]. Propranolol-mediated blockade of β-adrenergic receptors (β-ARs) significantly reduces behavioral expression of Pavlovian threat conditioning (PTC), whereas systemic activation of β2-ARs using Procaterol enhances it[3].Procaterol hydrochloride is freshly dissolved in 0.9% sterile saline immediately prior to injections[3]. Animal Model: |
| Name | Procaterol hydrochloride |
| CAS | 62929-91-3 |
| Formula | C16H23ClN2O3 |
| Molar Mass | 326.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. C Atgié, et al. Role of beta1- and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes. Am J Physiol. 1997 Oct;273(4):C1136-42. [2]. Zheng Deng, et al. Procaterol but not dexamethasone protects 16HBE cells from H2O2-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. [3]. Yiran Gu, et al. A brainstem-central amygdala circuit underlies defensive responses to learned threats. Mol Psychiatry. 2020 Mar;25(3):640-654. |
Procaterol hydrochloride
CAS: 62929-91-3 F: C16H23ClN2O3 W: 326.82
Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 µM. Procate
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