Procaspase-3/6 activator 1_product_DataBase

Bioactivity	Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7[1].
Invitro	将 100 nM 的 Procaspase-3 与 Procaspase-3/6 activator 1 (compound 1541) (100 nM 至 100 μM) 一起孵育。在 37°C 下孵育 4 小时后，通过添加 Ac-DEVD-AFC 来测定样品的 caspase 活性。低浓度的 1541 可诱导 procaspase-3 活性，EC50 为 2.4 μM，高浓度时可抑制 procaspase-3，IC50 为 34.0 μM[1]。Procaspase-3/6 activator 1 (compound 1541) 对活性 caspase-3 具有类似的抑制作用 (IC50 = 35 μM)，如 procaspase-3[1]。 0 --> Procaspase-3/6 activator 1 相关抗体:
Name	Procaspase-3/6 activator 1
CAS	1100353-03-4
Formula	C24H17N3O4
Molar Mass	411.41
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Wolan DW, et al. Small-molecule activators of a proenzyme. Science. 2009 Nov 6;326(5954):853-8.

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