| Bioactivity | Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. | ||||||||||||
| Target | Probucol (DH-581) is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol (DH-581) inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. Probucol (DH-581) is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol. | ||||||||||||
| Name | Probucol | ||||||||||||
| CAS | 23288-49-5 | ||||||||||||
| Formula | C31H48O2S2 | ||||||||||||
| Molar Mass | 516.84 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Probucol |