| Bioactivity | ProINDY, a prodrug of INDY (HY-108476), is a DYRK1A and DYRK1B inhibitor. ProINDY effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression[1]. |
| Invitro | 在过表达 Dyrk1A 或 xDyrk1A 的培养细胞中，ProINDY 抑制 tau 蛋白 Thr212 的磷酸化。ProINDY 还挽救了 Dyrk1A 过表达细胞中的 NFAT 通路，证实了相同的 Dyrk1A 抑制作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ProINDY 相关抗体: |
| CAS | 719277-30-2 |
| Formula | C14H15NO3S |
| Molar Mass | 277.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Y Ogawa et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86. |