Pro8-Oxytocin_product_DataBase

Bioactivity	Pro8-Oxytocin is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a[1].
Invitro	Pro8-Oxytocin (1 nM-10 μM) 能够激活 CHO 细胞AVPR1a 的 Ca2+ 动员[1]。
In Vivo	Pro8-Oxytocin 以更高的亲和力结合灵长类动物 OXTR（在表达 Pro8-OXT 和 Leu8-OXT 的灵长类动物中）并产生比 Leu8-OXT 更强的钙信号传导反应[1]。
Name	Pro8-Oxytocin
CAS	24327-19-3
Sequence	Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Pro-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
Shortening	CYIQNCPPG-NH2 (Disulfide bridge: Cys1-Cys6)
Formula	C42H62N12O12S2
Molar Mass	991.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mustoe A, et al. Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors. Sci Rep. 2019 Oct 29;9(1):15480.

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