| Bioactivity | Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs). Primordazine B inhibits a process called Poly(A)-tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT). Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions[1]. |
| CAS | 339337-07-4 |
| Formula | C18H17N5O2S |
| Molar Mass | 367.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Youngnam N Jin, et al. Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells[J]. Nature chemical biology, 2018, 14(9): 844-852. |
Primordazine B
CAS: 339337-07-4 F: C18H17N5O2S W: 367.42
Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of s
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