| Bioactivity | Prifuroline is an antiarrhythmic agent. |
| In Vivo | Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1]. |
| Name | Prifuroline |
| CAS | 70833-07-7 |
| Formula | C14H16N2O |
| Molar Mass | 228.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7. |