| Bioactivity | Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1]. |
| In Vivo | 在小鼠 NZB/NZW 狼疮模型和胶原性关节炎 (CIA) 模型中，Prezalumab 比单一 ICOSL 或 BAFF 抑制剂更有效[1]。Prezalumab 减少食蟹猴的 B 细胞，其药理作用与 BAFF 抑制剂相同[1]。 |
| Name | Prezalumab |
| CAS | 1523164-68-2 |
| Appearance | Liquid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914. |