Pranoprofen_product_DataBase

Bioactivity

Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2].

Invitro

Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells[1].Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells[3].

In Vivo

Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice[3].Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs. Animal Model:

Name

Pranoprofen

CAS

52549-17-4

Formula

C15H13NO3

Molar Mass

255.27

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Toru Hosoi, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54(1):1-6. [2]. Minting Chen, et al. The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns. J Ophthalmol. 2020 Apr 6;2020:7485912. [3]. Xiaoli Wu,et al. Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis. Theranostics. 2020 Apr 27;10(13):5749-5762.

PeptideDB

Pranoprofen

CAS: 52549-17-4 F: C15H13NO3 W: 255.27