| Bioactivity | Pramocaine-d9 (hydrochloride) is deuterium labeled Pramocaine (hydrochloride). Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. |
| Invitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| Name | Pramocaine-d9 (hydrochloride) |
| Formula | C17H19D9ClNO3 |
| Molar Mass | 338.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. SCHMIDT JL, et al. The pharmacology of pramoxine hydrochloride: a new topical local anesthetic. Curr Res Anesth Analg. 1953 Nov-Dec;32(6:1):418-25. |
Pramocaine-d9 (hydrochloride)
CAS: F: C17H19D9ClNO3 W: 338.92
Pramocaine-d9 (hydrochloride) is deuterium labeled Pramocaine (hydrochloride). Pramocaine hydrochloride decreases the pe
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