| Bioactivity | Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). | ||||||||||||
| Invitro | Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2[1]. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9[2]. | ||||||||||||
| Name | Praeruptorin B | ||||||||||||
| CAS | 73069-28-0 | ||||||||||||
| Formula | C24H26O7 | ||||||||||||
| Molar Mass | 426.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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