| Bioactivity | Polyoxin B is a potent chitin synthase inhibitor (IC50=0.08 mM) and an effective antifungal agent[1]. |
| Target | IC50: chitin synthase |
| Invitro | Polyoxin B has anti-fungi effects in vitro, the MIC values are 32 μg/ml, 64 μg/ml, 64 μg/ml and 8 μg/ml, respectively against Candida albicans, Aspergillus flavus, Aspergillums fumigatus, and Cryptococcus neoformans[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Polyoxin B 相关抗体: |
| CAS | 19396-06-6 |
| Formula | C17H25N5O13 |
| Molar Mass | 507.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mi-Young Yoon, et al. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6 [2]. Qinggang Ji, et al. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176 |