| Bioactivity | Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3]. |
| Invitro | Polymyxin B (10 μg/mL，6 小时) 降低了人外周血单核细胞 (PBMC) 中的 TNF-α 和 IL-10 的产生[3]。 0 --> Polymyxin B 相关抗体: |
| In Vivo | Polymyxin B (5-20 mg/kg，静脉注射；每日 1 次，连续 7 天) 在 20 mg/kg 的浓度下到达 Sprague-Dawley 大鼠模型的肾毒性终点，在 5 mg/kg 的浓度下没有[2]。 |
| Name | Polymyxin B |
| CAS | 1404-26-8 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125. [2]. Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16. [3]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1. |