| Bioactivity | Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis[1][2][3]. |
| Invitro | Polyinosinic-polycytidylic acid potassium (20 ng/mL; 24 hours; WM793, WM278, WM239A, WM9 and 1205Lu cells) 抑制细胞生长活性[1].Polyinosinic-polycytidylic acid potassium (200 ng/mL; 24 hours; 1205Lu cells) 诱导 1205Lu 细胞凋亡[1]。Polyinosinic-polycytidylic acid potassium (5 ng/mL; 24 hours; 1205Lu cells) 诱导黑素瘤细胞中的 IFN-β 表达。RIG-I 和 MDA-5 的沉默证实 Polyinosinic-polycytidylic acid potassium 诱导 IFN-β 分别需要 RIG-I 和 MDA-5，并且需要 IPS-1[1]。Polyinosinic-polycytidylic acid potassium 重悬于无菌盐水中，以 2 mg/ml 的浓度加热至 50 °C 以确保完全溶解，然后自然冷却至室温以确保双链 RNA 的适当退火，从而制备用于注射的 Polyinosinic-polycytidylic acid potassium. Poly I:C 储存在 -20 °C 直至使用[3]。 Cell Viability Assay[1] Cell Line: |
| Name | Polyinosinic-polycytidylic acid potassium |
| CAS | 31852-29-6 |
| Formula | (C10H13N4O8P)x.(C9H14N3O8P)x.xK |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Polyinosinic-polycytidylic acid potassium
CAS: 31852-29-6 F: (C10H13N4O8P)x.(C9H14N3O8P)x.xK W:
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agon
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