| Bioactivity | Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively[1]. |
| Target | IC50: 30 nM (Mpro). |
| CAS | 175669-29-1 |
| Formula | C22H26Cl2N6O2S2 |
| Molar Mass | 541.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang J, et al. An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting Mpro. Bioorg Med Chem Lett. 2024;103:129706. |
Polycarpine hydrochloride
CAS: 175669-29-1 F: C22H26Cl2N6O2S2 W: 541.52
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa
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