| Bioactivity | Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer [1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer [2]. |
| Invitro | Plaunotol (0, 10, 20 或 40 μM, 24 或 48 h) 对人结肠癌细胞系 DLD1 细胞增殖有显著抑制作用[2]。Plaunotol (40 μM, 24 或 48 h) 诱导人结肠癌细胞系 DLD1 细胞凋亡[2]。Plaunotol (0, 10, 20 或 40 μM, 48 h) 可激活人结肠癌细胞系 DLD1 中的半胱天冬蛋白酶-3[2]。 0 --> Plaunotol 相关抗体: Cell Proliferation Assay[2] Cell Line: |
| In Vivo | Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中具有显著减轻其胃粘膜损伤程度的作用[3]。Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中不会影响血清血清素、组胺浓度以及胃粘膜血流量[3]。Plaunotol (10, 25 或 50 mg/kg, 口服, 3 h) 在经 C48/80 处理雄性维斯塔大鼠中显著减弱了胃粘膜髓过氧化物酶 (MPO) 活性和脂质过氧化物硫代巴比妥酸反应物质 (TBARS) 含量[3]。 Animal Model: |
| Name | Plaunotol |
| CAS | 64218-02-6 |
| Formula | C20H34O2 |
| Molar Mass | 306.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. S. Songkro, et al. Investigation of plaunoi-loaded micro/nanoemulsions for the treatment of dermatitis: formulation, evaluation and skin irritation studies. J. DRUG DEL. SCI. TECH. 2011 21 (5) 401-410. [2]. Oshikawa N, et al. Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. J Surg Res. 2009 May 15;153(2):246-53. [3]. Ohta Y, et al. Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacology. 2005 Jul;74(4):182-92. |