| Bioactivity | Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D[1][2]. | ||||||||||||
| Invitro | Platycodin D (4 μM；24 h) 增加 Ucp1、Pgc1a、Sirt3、Cytc、Nrf1 和 Prdm16 的基因表达，抑制 3T3-L1 脂肪细胞中脂肪因子基因 Fabp4、Adipoq、Lipin1 的表达，抑制 hAMSCs 中 Fabp4、Adipoq 和抵抗素的表达[1]。Platycodin D (2 和 10 μM) 分别抑制小鼠和人脂肪细胞的脂质积累[1]。Platycodin D 抑制 PPARγ 和 C/EBPα 的蛋白表达，增加 UCP1、PGC1α、SIRT3、CIDEA 和 LIPIN1 蛋白表达水平[1]。Platycodin D (10 μM) 抑制脂滴形成，降低脂代谢相关 FABP4 蛋白的表达及 PPARγ 和 C/EBPα 的表达[2]。Platycodin D (10 μM；0-7 d) 恢复 CCND1 mRNA 水平，增加 PPARδ 水平[2]。 | ||||||||||||
| Name | Platycodin D | ||||||||||||
| CAS | 58479-68-8 | ||||||||||||
| Formula | C57H92O28 | ||||||||||||
| Molar Mass | 1225.32 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Platycodin D
CAS: 58479-68-8 F: C57H92O28 W: 1225.32
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity prope
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