| Bioactivity | Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis[1][2][3]. | |||||||||
| Invitro | Pladienolide B (0.1-2 nM; 24-72 hours) inhibits human cervical carcinoma cells viability[3].Pladienolide B (0.1-2 nM; 24-48 hours) reduces SF3b1 expression in human cervical carcinoma cells[3].Pladienolide B induces (0.1-2 nM; 24 hours) cell cycle arrest and apoptosis[3]. Cell Viability Assay[3] Cell Line: | |||||||||
| Name | Pladienolide B | |||||||||
| CAS | 445493-23-2 | |||||||||
| Formula | C30H48O8 | |||||||||
| Molar Mass | 536.70 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Pladienolide B
CAS: 445493-23-2 F: C30H48O8 W: 536.70
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide
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