| Bioactivity | Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1]. |
| Invitro | Placulumab (0.01-1000 µg/mL) 对 NS0 细胞和外周血单个核细胞 (PBMC) 具有细胞毒性[1]。 |
| In Vivo | Placulumab (0.3、1、3 和 10 mg/kg；腹腔注射；每周两次持续 8 周) 在 Tg197 转基因小鼠模型中具有有效的抗关节炎特性[1]。Placulumab 在食蟹猴中的药代动力学 (PK) 参数[1]Route |
| Name | Placulumab |
| CAS | 945781-29-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gay RD, et al. Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size. MAbs. 2010 Nov-Dec;2(6):625-38. |