| Bioactivity | Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 µM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both drug-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1]. |
| Target | IC50: 1.30 µM (Pks13-TE). |
| Invitro | Pks13-TE inhibitor 2 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0039-0.0078 μg/mL[1]. Cell Viability Assay[1] Cell Line: |
| Name | Pks13-TE inhibitor 2 |
| Formula | C22H19NO5 |
| Molar Mass | 377.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang W, et al. Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. J Med Chem. 2022 Oct 13;65(19):13240-13252. |