| Bioactivity | Piperidine 4-carbaldehyde (Piperidine 4-carboxaldehyde) acts as the Linker of the PROTAC (HY-161708) molecule of FLT3/CDKs, PROTAC of FLT3/CDKs is designed to treat certain diseases, such as acute myeloid leukemia (AML), by inducing the degradation of specific proteins. In this case, Piperidine 4-carbaldehyde was used to optimize the binding affinity to the target protein, thereby increasing the degradation efficiency of PROTAC molecules[1]. |
| CAS | 50675-20-2 |
| Formula | C6H11NO |
| Molar Mass | 113.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu M, et al. Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML[J]. European Journal of Medicinal Chemistry, 2024: 116539. |
Piperidine-4-carbaldehyde
CAS: 50675-20-2 F: C6H11NO W: 113.16
Piperidine 4-carbaldehyde (Piperidine 4-carboxaldehyde) acts as the Linker of the PROTAC (HY-161708) molecule of FLT3/CD
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