Piperacillin hydrate

CAS: 66258-76-2 F: C23H29N5O8S W: 535.57

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity

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Bioactivity	Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418)[1][2][3].
Invitro	Piperacillin (12.5 μg/mL, 24h) hydrate 对铜绿假单胞菌、粘质沙雷氏菌、大肠埃希菌、克雷伯氏菌和肠杆菌分别有 92%、82%、73%、61% 和 42% 的抑制作用，变形杆菌属大部分对其极敏感。大量接种时 Piperacillin hydrate 不能抑制革兰阴性杆菌的生长 (最低抑菌浓度 > 25 μg/mL) [2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Piperacillin hydrate 相关抗体:
In Vivo	Piperacillin (100 mg/kg, 静脉注射, 一日四次, 5 天) hydrate 联合 Tazobactam (HY-B1418) (12.5 mg/kg, 静脉注射, 一日四次, 5 天) 可延长肺炎克雷伯菌低接种量小鼠的生存时间[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	66258-76-2
Formula	C23H29N5O8S
Molar Mass	535.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13(3):358-67. [2]. Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14(1):78-87. [3]. Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20(11):O831-9.

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