| Bioactivity | Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections[1][2]. |
| Invitro | Pipemidic acid trihydrate 是 DNA 促旋酶的抑制剂，DNA 促旋酶是一种催化 ATP 依赖性 DNA 负超螺旋的细菌酶[2]。 |
| In Vivo | Pipemidic acid (50 mg/kg) trihydrate 口服吸收良好，在小鼠、大鼠、犬、猴中血浆峰浓度范围为 4~12 μg/mL[3]。Pipemidic acid trihydrate 在小鼠单次口服后的平均致死剂量超过 16000 mg/kg[3]。 |
| Name | Pipemidic acid trihydrate |
| CAS | 72571-82-5 |
| Formula | C14H23N5O6 |
| Molar Mass | 357.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Iacovino R, et al. β-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: characterization and bioactivity evaluation. Int J Mol Sci. 2013 Jun 25;14(7):13022-41. [2]. Aoyama H, et, al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. [3]. Shimizu M, et, al. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Apr;7(4):441-6. |
Pipemidic acid trihydrate
CAS: 72571-82-5 F: C14H23N5O6 W: 357.36
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits
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