| Bioactivity | Pinacidil (P-1134) monohydrate, an antihypertensive drug, is a potassium channel activator. |
| Invitro | Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3]. |
| Name | Pinacidil monohydrate |
| CAS | 85371-64-8 |
| Formula | C13H21N5O |
| Molar Mass | 263.34 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86. [2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5. [3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. |