| Bioactivity | Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. |
| CAS | 1777721-70-6 |
| Formula | C20H19F2N5O2.HCl.1/2H2O |
| Molar Mass | 444.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Smee DF, et al. Activities of JNJ63623872 and GS 4071 against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. [2]. Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31. [3]. Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):1990-4. [4]. Byrn RA, et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82. |
Pimodivir hydrochlorid hemihydrate
CAS: 1777721-70-6 F: C20H19F2N5O2.HCl.1/2H2O W: 444.87
Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through
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