| Bioactivity | Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the Ca2+-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Piezo1 agonist 1-d2 ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model[1]. |
| Target | EC50: 2.21 μM (Piezo1) |
| CAS | 3058199-62-2 |
| Formula | C16H13D2Cl2N5OS2 |
| Molar Mass | 430.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang H, et al., Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl)pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis. J Med Chem. 2024 Nov 14;67(21):19837-19851. |
Piezo1 agonist 1-d2
CAS: 3058199-62-2 F: C16H13D2Cl2N5OS2 W: 430.37
Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.