| Bioactivity | Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19[1][2][3][4]. | ||||||||||||
| Invitro | Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 cells and Caov-4 cells, respectively[2].Piclidenoson (0.0001-100 μM; 48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines, with IC50s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 cells, respectively[2].Piclidenoson (0.001-100 μM; 48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway[2].Piclidenoson induces apoptosis via the mitochondrial signaling pathway[2]. Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | Piclidenoson | ||||||||||||
| CAS | 152918-18-8 | ||||||||||||
| Formula | C18H19IN6O4 | ||||||||||||
| Molar Mass | 510.29 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Piclidenoson
CAS: 152918-18-8 F: C18H19IN6O4 W: 510.29
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenos
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.