| Bioactivity | Physachenolide C is a potent and selective BET inhibitor that induces apoptosis and arrests the cell cycle in the G0-G1 phase, with antitumor activity[1]. |
| Invitro | Physachenolide C (0.01-10 μM, 48 h) 作用于小鼠黑色素瘤细胞系 YUMM2.1和 YUMMER1.7 的 IC50 值分别是 0.5159 μM 和 1.8230 μM，并且导致早期凋亡细胞显着增加, 使细胞停滞在 G0-G1 期[1]。 |
| In Vivo | Physachenolide C (20 mg/kg IT daily for 15 doses) 在黑色素瘤小鼠模型中可以显著抑制剂肿瘤的生长，并使肿瘤完全消退，对小鼠无明显毒性作用。同时，使用 Physachenolide C 治疗的肿瘤具有显着增加的 TUNEL 阳性细胞百分比 (40%)[1]。 |
| Name | Physachenolide C |
| Formula | C30H40O9 |
| Molar Mass | 544.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Anngela C Adams, et al. Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest. Transl Oncol. 2022 Jan;15(1):101259. |