| Bioactivity | Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1]. |
| Target | Kd: 150 nM (p67phox) |
| Invitro | Phox-I2 可有效抑制 dHL-60 细胞和原代人中性粒细胞中 NOX2 介导的超氧化物产生，并具有剂量依赖性，且没有可检测到的细胞毒性[1]。 |
| Name | Phox-I2 |
| CAS | 353495-22-4 |
| Formula | C18H15N3O4 |
| Molar Mass | 337.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42. |