| Bioactivity | Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications. |
| Invitro | Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1]. |
| Name | Photo-lysine |
| CAS | 1863117-91-2 |
| Formula | C6H12N4O2 |
| Molar Mass | 172.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2. |
Photo-lysine
CAS: 1863117-91-2 F: C6H12N4O2 W: 172.19
Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifi
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.