| Bioactivity | Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3]. |
| Target | AChE; β-amyloid precursor protein; β-amyloid peptide |
| Invitro | Phenserine (1-25 μM；48 小时；CHO APP751SW 细胞)，10 μM Phenserine 处理的 CHO APP751SW 细胞显示细胞减少 18.6%，而 25 μM Phenserine 的浓度使 APP 水平降低了 51.4%[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Phenserine tartrate 相关抗体: Western Blot Analysis[2] Cell Line: |
| In Vivo | Phenserine (1-4 mg/kg；腹膜内注射；持续 4 天；雄性 Fischer-344 大鼠) 处理可改善空间记忆任务中胆碱能功能受损时的学习[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 156910-61-1 |
| Formula | C24H29N3O8 |
| Molar Mass | 487.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97. [2]. Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75(5):684-99. [3]. https://www.ncbi.nlm.nih.gov/pubmed/24687915 |
Phenserine tartrate
CAS: 156910-61-1 F: C24H29N3O8 W: 487.50
Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, lo
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