| Bioactivity | Phenindione is an anticoagulant which functions as a Vitamin K antagonist.Target: OthersPhenindione(Rectadione) is an anticoagulant which functions as a Vitamin K antagonist. A lymphocyte transformation test showed proliferation of T-cells from the hypersensitive patient, but not from four controls on exposure to phenindione in vitro. Drug-specific T-cell clones were generated and characterized in terms of their phenotype, functionality, and mechanism of antigen presentation. Forty-three human leukocyte antigen class II restricted CD4+ αβ T-cell clones were identified. T-cell activation resulted in the secretion of interferon-γ and interleukin-5 [1]. | ||||||||||||
| Name | Phenindione | ||||||||||||
| CAS | 83-12-5 | ||||||||||||
| Formula | C15H10O2 | ||||||||||||
| Molar Mass | 222.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Naisbitt, D.J., et al., Characterization of the T-cell response in a patient with phenindione hypersensitivity. Journal of Pharmacology and Experimental Therapeutics, 2005. 313(3): p. 1058-1065. |