Phanginin A_product_DataBase

Bioactivity	Phanginin A is a potent and orally active SIK1 (salt-induced kinase 1) activator. Phanginin A inhibited gluconeogenesis. Phanginin A increases the expression of p-SIK1 and decreases the expression of p-CREB. Phanginin A reduces blood glucose levels and improves glucose tolerance and dyslipidemia. Phanginin A has the potential for the research of type 2 diabetes[1].
Invitro	Phanginin A (2.5, 5, 10 µM) 以剂量依赖性方式抑制原代小鼠肝细胞中的糖异生[1]。Phanginin A (5, 10 µM) 降低 G6P 和 PEPCK 的 mRNA 表达，并减少细胞内 cAMP 的积累[1]。Phanginin A (5, 10 µM; 0-120 min) 以时间和剂量依赖的方式抑制原代小鼠肝细胞中 CREB 磷酸化的表达[1]。Phanginin A (2.5, 5, 10 µM; 0-120 min) 以时间和剂量依赖的方式增加原代小鼠肝细胞中 p-SIK1 的表达[1]。Phanginin A (5, 10 µM) 增加 PDE4 活性[1]。 RT-PCR[1] Cell Line:
In Vivo	Phanginin A (100 mg/kg; p.o.; once) 在 2 型糖尿病 ob/ob 小鼠中表现出抗糖异生活性[1]。Phanginin A (100 mg/kg; p.o.; once daily for 26 days) 改善 ob/ob 小鼠的代谢紊乱[1]。 Animal Model:
Name	Phanginin A
CAS	1011528-58-7
Formula	C21H28O5
Molar Mass	360.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu S, et al. Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway. Mol Metab. 2020 Nov;41:101045.

PeptideDB

Phanginin A

CAS: 1011528-58-7 F: C21H28O5 W: 360.44