| Bioactivity | Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC50 of 0.15 and 1.25 μM[1]. |
| CAS | 186180-20-1 |
| Sequence | Met-Pro-Arg-Phe-Met-Asp-Tyr-Trp-Glu-Gly-Leu-Asn |
| Shortening | MPRFMDYWEGLN |
| Formula | C71H99N17O19S2 |
| Molar Mass | 1558.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu B, et al., Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7. |
Phage-derived 12/1 peptide
CAS: 186180-20-1 F: C71H99N17O19S2 W: 1558.78
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX
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